2 edition of Association between birth defects and exposure to ambient vinyl chloride found in the catalog.
Association between birth defects and exposure to ambient vinyl chloride
Gilles P Theriault
by U.S. Environmental Protection Agency, Health Effects Research Laboratory, Center for Environmental Research Information [distributor] in Research Triangle Park, NC, Cincinnati, OH
Written in English
|Statement||Gilles P. Theriault, Hilda Iturra, and Suzanne Gingras|
|Contributions||Iturra, Hilda, Gingras, Suzanne, Health Effects Research Laboratory (Research Triangle Park, N.C.)|
|The Physical Object|
|Pagination||6 p. :|
Vinyl Chloride In Groundwater What is vinyl chloride? Vinyl chloride is a colorless gas that, at high levels, has a mild, sweet odor. Vinyl chloride is a manufactured substance, used mostly to make polyvinyl chloride (PVC) plastic products. Vinyl chloride can enter the air, soil and groundwater following improper disposal of chemical wastes. Several industry-based cohort studies have addressed the risk of lung cancer following exposure to vinyl chloride, acrylonitrile and styrene, with inconsistent results and usually without smoking adjustment. These exposures are addressed here in a large case–control study with full adjustment for smoking. Almost subjects were included in a case–control study conducted in seven Cited by:
Exposure and Risk. In the United States, about 3% of babies are born with structural birth defects. Most birth defects are thought to be caused by a complex mix of genetic, behavioral, and environmental factors, although, for many birth defects, exactly how these factors work together is unclear. Objectives. The hypothesis of this study was that metabolites of trichloroethylene (TCE), dichloroethylene (DCE) and related compounds were responsible for fetal cardiac teratogenic effects seen when TCE or DCE is consumed by pregnant rats during organogenesis. Identification of teratogenic metabolites would allow more accurate assessment of environmental contaminants and public health Cited by:
The vinyl chloride-related cancer incidence probability cal- culations by Kuzmack and McGaughy () provide the best available quantitative estimate of the risk resulting from vinyl chloride inhalation exposure of a large segment of U.S. human population living in the vicinity of vinyl chloride-polymerization and fabri- cation plants. solvents during pregnancy suggest an association of tetrachloroethylene exposure with birth defects, however firm conclusions cannot be drawn due to several limitations of these studies. (2) Increased fetal resorptions and effects to the fetus have been reported in animals exposed to high levels of tetrachloroethylene by inhalation. (2).
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Association between birth defects and exposure to ambient vinyl chloride. Research Triangle Park, NC: U.S. Environmental Protection Agency, Health Effects Research Laboratory ; Cincinnati, OH: Center for Environmental Research Information [distributor], (OCoLC) Material Type.
Chronic (long-term) exposure to vinyl chloride through inhalation and oral exposure in humans has resulted in liver damage. Cancer is a major concern from exposure to vinyl chloride via inhalation, as vinyl chloride exposure has been shown to increase the risk of a rare form of liver cancer in humans.
Vinyl chloride is an organochloride with the formula H 2 C=CHCl that is also called vinyl chloride monomer (VCM) or colorless compound is an important industrial chemical chiefly used to produce the polymer polyvinyl chloride (PVC).
About 13 billion kilograms are produced al formula: C₂H₃Cl. birth and parental occupational exposure to vinyl chloride (15). Another study of families reported no significant association between incidence of birth defects, and proximity of homes to vinyl chloride-contaminated sites (16), or ambient air vinyl chloride concentrations (17).
Since there has been a vinyl chloride polymerization plant in this town since from which ten cases of angiosarcoma of the liver have been identified, this study explores the possible association between exposure to vinyl chloride monomer (VCM) in ambient air and the occurrence of.
Theriault G, Iturra H, Gingras S. Evaluation of the association between birth defects and exposure to ambient vinyl chloride. Teratology ;– Related Government Documents. PUBLIC HEALTH STATEMENT Vinyl Chloride.
CAS#: Division of Toxicology and Environmental Medicine July If you breathe high levels of vinyl chloride, you will feel dizzy or sleepy. These effects occur within 5 minutes if you are exposed to ab ppm of vinyl chloride. You can easily smell vinyl chloride at this concentration.
The U.S. Occupational Safety & Health Administration provides information about exposure limits to vinyl chloride. Selected References: Agency for Toxic Substances and Disease Registry. Public Health Statement: Vinyl Chloride.
Atlanta, GA: Centers for Disease Control and Prevention, Available online. Last accessed Decem 3 Characterization of Neurobehavioral Effects. The National Research Council (NRC) report on contaminated drinking water at Camp Lejeune found that there was limited/suggestive evidence of an association between exposure to mixed solvents and neurobehavioral effects.
One case control study found no association between incidence of central nervous system defects in infants at birth and parental occupational exposure to vinyl chloride (15).
Another study of families reported no significant association between incidence of birth defects, and proximity of homes to vinyl chloride-contaminated sites (16), or. Vinyl chloride also causes cancer in laboratory animals following lifetime inhalation or oral exposure, predominately in the liver.
Available human evidence is inadequate to determine if there is an increased risk of abortion or birth defects with exposure to vinyl chloride. Keith G. Tolman, Anthony S. Dalpiaz, in Drug-Induced Liver Disease (Third Edition), Vinyl Chloride. Vinyl chloride is an organochloride, flammable gas with a sickly sweet odor, which is a colorless at ambient temperature.
Discovered init is used as an intermediate in the production of polyvinyl chloride (PVC), which is molded into PVC piping and bottles. Two previous studies investigated the association between ambient benzene exposure and risk of birth defects.
Lupo et al. conducted a study in Texas and found evidence of a positive association between spina bifida and maternal exposure to benzene (Lupo et al., ).Cited by: South Africa is one of the major users of pesticides on the African continent.
The Eastern Cape is the second largest province in South Africa. There has been growing concern about the occurrence of certain birth defects which seemed to have increased in the past few years.
In this paper we investigate associations between exposure to agricultural chemicals and certain birth by: QUANTITATIVE RISK ASSESSMENT FOR COMMUNITY EXPOSURE TO VINYL CHLORIDE Arnold M.
Kuzmack Office of Planning and Evaluation U. Environmental Protection Agency Washington, D. and Robert E. McGaughy Office of Health and Ecological Effects U. Environmental Protection Agency Washington, 0. The latter study did find an association between exposure and preterm birth, most clearly related to increasing exposure levels in the later part of pregnancy.
Airborne exposures to PAH are found in smoking and urbanized environments, and associated with reduced growth (63, 65,) and shortened by: Oral Cleft Defects and Maternal Exposure to Ambient Air Pollutants in New Jersey Article in Birth Defects Research Part A Clinical and Molecular Teratology 88(4) April with 45 Reads.
Consequently, ambient concentrations of nitrogen dioxide (NO 2) and particular matter 10 micrometers or less (PM 10), were reduced in a distinct and short window of time, which presented a natural experiment for testing the relationships between maternal exposure to PM 10 and NO 2 during pregnancy and adverse birth by: An invisible and odorless gas, vinyl chloride has been linked to a variety of health concerns.
Some of the effects of vinyl chloride exposure include brain cancer, lung cancer, and liver cancer. People can be exposed to vinyl chloride by breathing airborne fumes or drinking contaminated water.
Theriault G, Ittura H, Gingras S () Evaluation of the association between birth defects and exposure to ambient vinyl chloride. Teratology – PubMed CrossRef Google ScholarCited by: 1.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.1 ppm = mg/m 3.
See: IDLH INDEX. Exposure Limits. Ca See Appendix A.  TWA 1 ppm C 5 ppm [minute] Measurement Methods. See: NMAM or OSHA Methods. Physical Description. Colorless gas or liquid (below 7°F) with a pleasant odor at high concentrations.
[Note: Shipped as a liquefied compressed gas.] Molecular Weight.Help from a Chemical Exposure Attorney. If you or a member of your family has been harmed by exposure to vinyl chloride, you may be legally entitled to compensation for your medical bills and other losses and expenses.
Contact an injury attorney skilled in .